Apogenin, Salt Intake & Overnight Urination, Lactate Dehydrogenase, Muscle Cramps

July 20, 2021

[00:01:40] Apogenin to downregulate CD38 and increase NAD+.

[00:07:08] Apogenin in foods.

[00:07:17] Quercetin may also down regulate CD38 activity.

[00:11:13] Podcast: How Oxidative Stress Impacts Performance and Healthspan.

Resources:

• Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
• CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats
• Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38
• Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
• Clinical Evidence for Targeting NAD Therapeutically

[00:12:55] Salt intake and overnight urination. Forum thread.

[00:16:28] Lactate Dehydrogenase (LDH) blood marker and LDH isoenzymes.

[00:18:56] Additional markers you might run: Creatine Kinase, ALT, Troponin.

[00:19:13] Other things that can cause elevated LDH.

Resources:

• Biochemistry, Lactate Dehydrogenase
• Elevated Creatine Kinase and Lactic Acid Dehydrogenase and Decreased Osteocalcin and Uncarboxylated Osteocalcin are Associated with Bone Stress Injuries in Young Female Athletes

[00:21:28] Cramping up during a race.

[00:23:00] Tommy Wood on Endurance Planet Podcast: Ask The Doc: Dr. Tommy Wood on Familial Hypercholesterolemia in Athletes, Restless Leg Syndrome, His ‘Elite Performance Analysis’ Test and Much More.

[00:23:54] Hotshot Sports Shot.

[00:26:46] Formula SF722.

[00:37:06] Correct Toes toe spacers.