How Not to Die of Cardiovascular Disease

March 11, 2018

Ivor Cummins is a Biochemical Engineer who in 2012 was disturbed by a set of his own abnormal blood test results. Consultation with multiple doctors yielded little insight into the cause of his elevated cholesterol, ferritin and GGT so he turned to his analytical roots to study the problem. In the process, he evaluated hundreds of scientific papers, ultimately concluding that that flawed hypotheses and a breach of the scientific method have resulted in the current “diabesity” epidemic.

Ivor is here today with Dr. Tommy Wood talking on topics related to his well-referenced new book, Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health. They also discuss the trouble with polyunsaturated oils, advice on fat loss for the insulin sensitive, and the best test for cardiovascular disease risk (hint: it’s not LDL). If you enjoy this podcast, Ivor is a regular presenter at low-carb/keto events and maintains an active blog and social media presence.

Here’s the outline of this interview with Ivor Cummins:

[00:00:17] Keto Summit, Dave Feldman.

[00:00:48] Boundless Health Podcast with Dr. Bret Scher.

[00:01:57] Podcast: The True Root Causes of Cardiovascular Disease, with Dr. Jeffry Gerber.

[00:02:15] Book: Eat Rich, Live Long: Mastering the Low-Carb & Keto Spectrum for Weight Loss and Great Health, by Ivor Cummins and Jeffry Gerber, MD.

[00:02:29] Videos: here and here.

[00:03:20] Insulin, IGF-1, acellular carbs.

[00:03:56] Sunlight exposure, 25-OH-D video.

[00:04:37] Minerals, Study: DiNicolantonio, James J., James H. O’Keefe, and William Wilson. "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis." Open Heart 5.1 (2018): e000668.

[00:05:28] Gabor Erdosi, Lower Insulin Facebook Group.

[00:05:43] Video: Roads to Ruin? from Physicians for Ancestral Health 2017 conference.

[00:06:01] Guðmundur Jóhannsson, gut health; Podcast: Foodloose Iceland.

[00:07:40] Study: Schwalfenberg, Gerry K., and Stephen J. Genuis. "The importance of magnesium in clinical healthcare." Scientifica 2017 (2017).

[00:08:10] Industrial seed oils.

[00:09:05] Unilever sells its margarine business.

[00:10:17] Studies: Alvheim, Anita Røyneberg, et al. "Dietary Linoleic Acid Elevates the Endocannabinoids 2‐AG and Anandamide and Promotes Weight Gain in Mice Fed a Low Fat Diet." Lipids 49.1 (2014): 59-69. And: Alvheim, Anita R., et al. "Dietary Linoleic Acid Elevates Endogenous 2‐AG and Anandamide and Induces Obesity." Obesity 20.10 (2012): 1984-1994.

[00:10:48] Studies: Nanji, Amin A., and Samuel W. French. "Dietary factors and alcoholic cirrhosis." Alcoholism: Clinical and Experimental Research 10.3 (1986): 271-273. And: Kirpich, Irina A., et al. "Alcoholic liver disease: update on the role of dietary fat." Biomolecules 6.1 (2016): 1.

[00:12:09] Book: Deep Nutrition: Why Your Genes Need Traditional Food, by Cate Shanahan, M.D.

[00:12:45] Studies: 1. Ramsden, Christopher E., et al. "The Sydney Diet Heart Study: a randomised controlled trial of linoleic acid for secondary prevention of coronary heart disease and death." The FASEB Journal 27.1 Supplement (2013): 127-4. 2. Frantz, Ivan D., et al. "Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey." Arteriosclerosis, Thrombosis, and Vascular Biology 9.1 (1989): 129-135. 3. Strandberg, Timo E., et al. "Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study." Heart 74.4 (1995): 449-454. 4. Rose, G. A., W. B. Thomson, and R. T. Williams. "Corn oil in treatment of ischaemic heart disease." British medical journal 1.5449 (1965): 1531.

[00:13:47] Study: Hooper, Lee, et al. "Reduction in saturated fat intake for cardiovascular disease." The Cochrane Library (2015).

[00:15:28] Study: Ip, Clement, Christopher A. Carter, and Margot M. Ip. "Requirement of essential fatty acid for mammary tumorigenesis in the rat." Cancer Research 45.5 (1985): 1997-2001.

[00:16:28] Study: Pearce, Morton Lee, and Seymour Dayton. "Incidence of cancer in men on a diet high in polyunsaturated fat." The Lancet 297.7697 (1971): 464-467.

[00:16:56] Breast milk composition is now almost 50% PUFA.

[00:17:50] David Bobbett.

[00:19:59] Book structure.

[00:20:51] Fat-loss for the insulin sensitive.

[00:21:10] Videos: Jeff Gerber interviews Simon Saunders and Marty Kendall.

[00:23:03] Ghrelin.

[00:24:21] Protein and lean body mass.

[00:26:05] Glucagon, mTOR.

[00:26:22] Ron Rosedale.

[00:26:34] Valter Longo.

[00:27:02] IGF-1 U-shaped curve.

[00:28:06] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417.

[00:28:49] Book: Protein Power: The High-Protein/Low Carbohydrate Way to Lose Weight, Feel Fit, and Boost Your Health - in Just Weeks! By Michael Eades and Mary Dan Eades.

[00:30:39] Study: Levine, Morgan E., et al. "Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population." Cell metabolism 19.3 (2014): 407-417.

[00:31:06] NHANES.

[00:31:18] Study: Cohen, Evan, et al. "Statistical review of US macronutrient consumption data, 1965–2011: Americans have been following dietary guidelines, coincident with the rise in obesity." Nutrition 31.5 (2015): 727-732.

[00:32:20] Kitavans.

[00:34:05] Hyperlipid and Denise Minger.

[00:36:37] Icelandic diets for longevity

[00:39:07] Cardiovascular disease.

[00:39:35] Basic lipid panel.

[00:39:45] Study: Castelli, William P. "Lipids, risk factors and ischaemic heart disease." Atherosclerosis 124 (1996): S1-S9.

[00:40:24] Ratios.

[00:41:54] Study: Johnson, Kevin M., David A. Dowe, and James A. Brink. "Traditional clinical risk assessment tools do not accurately predict coronary atherosclerotic plaque burden: a CT angiography study." American Journal of Roentgenology 192.1 (2009): 235-243. Commentary: Ware, William R. "The mainstream hypothesis that LDL cholesterol drives atherosclerosis may have been falsified by non-invasive imaging of coronary artery plaque burden and progression." Medical hypotheses 73.4 (2009): 596-600.

[00:42:30] Familial Hypercholesterolemia and CVD.

[00:43:27], remnant cholesterol, Plasma Atherogenic Index.

[00:44:36] Podcast: Health Outcome-Based Optimal Reference Ranges for Cholesterol

[00:46:06] Coronary calcium scan.

[00:46:25] Study: Nasir, Khurram, et al. "Interplay of Coronary Artery Calcification and Traditional Risk Factors for the Prediction of All-Cause Mortality in Asymptomatic Individuals Clinical Perspective." Circulation: Cardiovascular Imaging 5.4 (2012): 467-473.

[00:47:54] Longitudinal score.

[00:49:41] Plaque density.

[00:50:11] Interview with Matt Budoff.

[00:52:37] Video: Dr. Eades at Low Carb Breckenridge, Agatston score.

[00:54:38] The Fat Emperor.

[00:54:53] Low-carb Breckenridge 2018.

[00:55:10] Ketofest, Keto Con, Low-carb USA, Refind Health.

[00:55:45] Widowmaker movie.

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