How Do Coffee Enemas Increase Glutathione?

Written by Tommy Wood MD, PhD

Dec. 20, 2016

Before we've even had a chance to truly toxify our bodies over the Christmas holidays, the detox questions have started rolling in. One detox method that has gained some recent high-profile publicity is the coffee enema. In particular, coffee enemas are said to stimulate bile production and increase glutathione. This is very interesting, because glutathione is often considered to be the master antioxidant that controls multiple phases of detoxification and many aspects of cellular function.

So, assuming you cool your coffee first to avoid rectal burns,1 is there any evidence that coffee enemas aid detoxification and increase glutathione production?


Addendum and expansion

This article has generated quite a lot of discussion! However, while some people enjoyed the fact that it was brief and to-the-point, others felt that the lack of detail didn’t substantiate the light-hearted tone. Despite the brevity, the article was not written without detailed research.

Many patients and practitioners say they have gained benefit from using coffee enemas. Importantly, the article does not say that coffee enemas will not provide any benefit. In fact, it would probably be impossible to state that. I have prescribed many enemas in the hospital, and they do have their benefits. The question posed in the article is whether there is any scientific evidence that coffee enemas stimulate the movement of bile or production of glutathione. The short answer is that I have been unable to find any.

As an example of the information that is written about coffee enemas in the popular health media, read this article. I do not intend to single out the author (Dr. Axe), but I did listen to a recent high-profile podcast that essentially recited this article verbatim. That was the stimulus for my own article.

Dr. Axe’s article does include references that support the benefit of coffee consumption, of which I am in complete agreement with4. With regard to the glutathione-related benefits of coffee enemas, only one reference is provided, which involved giving green coffee beans (orally) to mice5.

There are actually multiple studies discussing the mechanistic benefits of coffee on various aspects of health, including glutathione production. However, unless I am mistaken, they are all based around coffee taken orally6,7. Importantly, oral administration of coffee leads to a different absorption profile compared to rectal administration8. This suggests that you cannot use studies of oral coffee intake to predict the effect of a coffee enema.

In the one study examining the effect of coffee enemas on glutathione in humans, no effect was seen9.

When discussing the cancer-fighting and bile-stimulating benefits of coffee enemas, most people refer to the original publications by Dr. Max Gerson describing Gerson therapy. While I am in no doubt that Dr. Gerson helped his patients, the described mechanisms and benefits of coffee enemas have not been borne out elsewhere in the literature.

If I were to contradict my own article, I might reference one study10 looking at the effect of coffee enemas on visibility of the small bowel (including presence of bile) on capsule video endoscopy. This study did show a potential benefit of the coffee enema, but did not compare coffee enemas to an enema without coffee. Therefore, the effect of the coffee cannot be ascertained. The authors even state that “Further studies are warranted to evaluate the safety and effectiveness of coffee enemas, as well as to analyze how coffee enemas affect bile excretion.”

It is very true that an absence of evidence is not an evidence of absence. If people feel they are benefitting from the use of coffee enemas, I have absolutely no issue with that. But when our clients are asking about the evidence supporting the benefit of coffee enemas, I must honestly say that I can’t find any. I would guess that hundreds or perhaps thousands of practitioners worldwide are using coffee enemas regularly, but none of them seem to have published their positive results. It would be simple to run studies looking at the benefits of coffee enemas. I have some experience designing, running, and publishing studies in both humans and animals, and if anybody wants to run a coffee enema study, I would be happy to help in any way I can.

At NBT we try to do the best with the information available, and the original article summarises our findings on the use of coffee enemas. If the evidence changes, we will gladly change our position!

P.S I was also directed to an article by Dr. Sarah Ballantyne (The Paleo Mom), which is very detailed and comes to much the same conclusion that I did.

P.P.S There was a suggestion that my reference for the risk of hot coffee enemas was inadequate. There are many published case reports that you can peruse at your leisure11-13.


  1. Jones LE, Norris WE. Rectal burn induced by hot coffee enema. Endoscopy. 2010;42 Suppl 2:E26.

  2. Cassileth B. Gerson regimen. Oncology (Williston Park). 2010 Feb;24(2):201.

  3. Teekachunhatean S, Tosri N, Sangdee C, Wongpoomchai R, Ruangyuttikarn W, Puaninta C, Srichairatanakool S. Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers. Hum Exp Toxicol. 2012 Jul;31(7):643-51.

  4. Butt, Masood Sadiq, and M. Tauseef Sultan. "Coffee and its consumption: benefits and risks." Critical reviews in food science and nutrition 51.4 (2011): 363-373.

  5. Lam, Luke KT, Velta L. Sparnins, and Lee W. Wattenberg. "Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse." Cancer Research 42.4 (1982): 1193-1198.

  6. Huber, Wolfgang W., and Wolfram Parzefall. "Modification of N‐Acetyltransferases and Glutathione S‐Transferases by Coffee Components: Possible Relevance for Cancer Risk." Methods in enzymology 401 (2005): 307-341.

  7. Huber, Wolfgang W., et al. "Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities." Environmental and molecular mutagenesis 44.4 (2004): 265-276.

  8. Teekachunhatean, Supanimit, et al. "Pharmacokinetics of caffeine following a single administration of coffee enema versus oral coffee consumption in healthy male subjects." ISRN pharmacology 2013 (2013).

  9. Teekachunhatean, S., et al. "Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers." Human & experimental toxicology 31.7 (2012): 643-651.

  10. Kim, Eun Sun, et al. "Coffee enema for preparation for small bowel video capsule endoscopy: a pilot study." Clinical nutrition research 3.2 (2014): 134-141.

  11. Sashiyama, Hiroshi, et al. "Rectal burn caused by hot-water coffee enema." Gastrointestinal endoscopy 68.5 (2008): 1008-1009.

  12. Jones, L. E., and W. E. Norris. "Rectal burn induced by hot coffee enema." Endoscopy 42.S 02 (2010): E26-E26.

  13. Keum, Bora, et al. "Proctocolitis caused by coffee enemas." The American journal of gastroenterology 105.1 (2010): 229.

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