June 26, 2017
Written by Megan Roberts, MSc, and Tommy Wood MD, PhD
With preparation inspiration and photo credits to Louise Hendon of Paleo Flourish Magazine
In the 1950’s a scientist by the name of Denham Harman first proposed the Free Radical Theory of Aging . The basic premise of the theory was that metabolic processes produce reactive byproducts that accumulate over time, damaging cells, and ultimately leading to aging and its associated diseases. Naturally, scientists attempted to mitigate the production of these reactive oxygen species, in hopes of coming one step closer to slowing the aging process. However, over many years it became apparent that these supposedly damaging metabolic byproducts actually function as very important signaling molecules. In fact, the benefits we get from things like exercise and drinking Hormetea are dependent on them! Needless to say, fast forward a few decades and today the simplistic theory has been debunked and we know that there is a Goldilocks zone for free radicals - we require some, but too many can wreak metabolic havoc.
Hormesis is the process whereby exposure to small amounts of a toxin or stressor has a physiological net benefit over time. Examples of hormetic stressors include exercise, temperature extremes, diets rich in colorful fruits and vegetables, and altitude-induced hypoxia. All of these temporarily stress the body in such a way that tells our cells to become stronger so that the body can better handle the stressor the next time around.
The Nrf2 pathway is our cell’s master antioxidant defense pathway and is activated by many kinds of oxidative stress. The pathway regulates expression of specific antioxidant and detoxification proteins that are critical to cellular health . Activation of the Nrf2 pathway provides protection against many of the environmental insults we experience on a day to day basis. Some of the compounds in plants that we think of as antioxidants are actually pro-oxidants and function to enhance activation of the Nrf2 pathway.
AMPK and SIRT1 (a protein in the sirtuin family) are two additional signaling molecules that when activated enhance mitochondrial function. Both of these molecules sense cellular energy homeostasis and nutrient balance, most notably in the context of calorie restriction and exercise. However, hormetic phytochemicals in plants such as polyphenols have also been shown to increase their activity .
Before we talk about the creation of Hormetea, let’s make we’re all on the same page with some definitions:
Polyphenols are a broad class of plant-based compounds that have a common phenol ring structure and give fruits, vegetables, spices, and herbs their vibrant colors and health-promoting properties. Plants that are deeply pigmented throughout will be highest in polyphenols (think dark berries, peppers, and beets). Polyphenols function to protect plants against pathogens and UV radiation.
Flavanoids are a type of polyphenol that share a common 2-ring structure. Flavanoids are divided into subclasses which include:
Flavonols (such as quercetin in berries)
Anthocyanins (which give berries their blue/purple color)
Flavanols (such as catechins in green tea).
Sulforaphane is a compound found in cruciferous vegetables and particularly concentrated in broccoli seeds and sprouts. Sulforaphane is a potent activator of the Nrf2 pathway and has many health benefits.
Hormetea was created by Tommy to be a convenient (and delicious) way to get a variety of these health-promoting compounds in one place. In one serving, you’ll find the best-researched plant polyphenols in doses that have been clinically-proven to reduce inflammation and improve metabolic health, with a touch of pepper to increase bioavailability. You can think of drinking Hormetea as a little intracellular workout. We’re sure you’re going to love it!
For the remainder of the article, we’ll dive into each of the ingredients in Hormetea and review the wide range of benefits each has to offer. Then we’ll discuss the best preparation techniques and answer a few of the most frequently asked questions.
Bilberry is a dark, Nordic wild blueberry that is rich in anthocyanins and quercetin. Bilberry has been shown to:
Reduce insulin and glucose response to carbs 
Improve glucose tolerance in obese individuals (when given with prebiotics) 
Improve symptoms in ulcerative colitis 
Reduce oxidative DNA damage 
Improve vascular function 
Improve gait speed and agility in the elderly 
The predominant polyphenols in green tea are called catechins, the most potent and well-known of which is EGCG. Matcha differs from regular green tea in that it is shade-grown and its leaves are ground into a fine powder after harvest. Because the whole tea leaves are consumed, Matcha is even higher in caffeine and catechins compared to standard green tea. The catechins found in green tea and Matcha have been shown to:
Improve insulin sensitivity and glucose tolerance 
Improve cognitive function in people with cognitive decline (along with L-theanine) 
Decrease carbohydrate absorption 
Interestingly, there is some evidence of synergy between different polyphenols. For example, quercetin increases the bioavailability of EGCG  - another reason to consume these compounds together in Hormetea!
Grape seed extract is, as the name suggests, extracted from grapes and has a brilliant red color. Much of the research on grape seed extract is in the area of metabolic disease. It has been shown to:
Improve blood pressure in individuals with pre-hypertension 
Improve inflammation and glycemic control in those with insulin resistance 
Reduce oxidized LDL 
Turmeric is a bright orange root, similar to ginger. Curcumin, the most bioactive constituent in turmeric, makes up about 1-5% of the root and has potent anti-inflammatory properties . Many of the benefits of turmeric have been contributed to curcumin in isolated form, so if you’re looking for something that will act as a systemic anti-inflammatory, best use a product such as . Turmeric has been shown to:
Reduce CRP levels (a marker of inflammation) 
Improve working memory after administering a carb load 
Combat indigestion 
Decrease gut permeability 
Broccoli seeds have some exciting health-promoting properties due to their high concentration of sulforaphane, a compound found in lesser amounts in other cruciferous vegetables. Many epidemiological studies have shown decreased cancer  and all-cause mortality  in people who consume lots of cruciferous vegetables, which may in part be due to higher intake of sulforaphane. If you’re eating lots of cruciferous plants on a daily basis, make sure you’re also getting enough dietary iodine from fish and seaweed, since cruciferous vegetables may be linked to thyroid cancer in those who are already iodine deficient . Many of the benefits of sulforaphane are likely due to its ability to activate the Nrf2 pathway. Broccoli sprouts, or their extracts, have been shown to:
Improve insulin resistance 
Exhibit neuroprotective effects 
Improve behavior (in Autism Spectrum Disorder) 
Improve markers of liver health and oxidative stress 
Aid in the detoxification of airborne pollutants 
That’s it for the ingredients. Check out the vibrant colors (compliments of the polyphenol content of these plant compounds) in the picture capturing the process of making Hormetea!
While you could just boil a kettle of water to prepare Hormetea, we don’t recommend it! There’s no need to get fancy with a thermometer, but following a few simple guidelines will allow you to maximize the activity of the health-promoting compounds in the tea.
Place 2 heaping teaspoons of Hormetea in a mug
Add hot water (around 70 degrees Celsius, or 158 degrees Fahrenheit) to the bottom of the mug, about ¼ of the way full
* Or, boil a kettle and let it sit for a few minutes before pouring
Let the mixture sit for 5-20 minutes
Top off with hot water of your preferred temperature
Julie Kelly also came up with the brilliant (and rather tasty) idea of adding Hormetea to bone broth. As Chris stated in a recent podcast, “It tastes like a [savory] green pea soup.”
We’re not trying to be neurotic with water temperatures… There is some logic behind the preparation method! Optimal matcha tea brewing temperatures are between 80-85 degrees Celsius (176-185 degrees Fahrenheit). Myrosinase, the enzyme in broccoli seeds that creates sulforaphane, is activated between 70-80 degrees Celsius (158-176 degrees Fahrenheit) . So, to protect the matcha leaves from becoming bitter and optimize sulforaphane production, we recommend using the multi-step process above with the water around 70 degrees Celsius.
Everyone! The polyphenols in Hormetea can benefit just about everybody, from individuals with metabolic derangement to hard-changing athletes to the average Joe on the street. Some of the compounds may particularly therapeutic for certain metabolic conditions, but anyone looking to optimize their health can reap the benefits of Hormetea.
Sure! A full 2 teaspoon serving of Hormetea will have about 60mg of caffeine, so while caffeine tolerant folks might not notice it, those who are caffeine naive or very sensitive likely will. Most people won’t get an ergogenic benefit per se, but many of the compounds in the tea target the same signaling pathways as exercise , so combining the two might yield a nice synergistic effect.
For those savvy folks thinking, haven’t supplemental antioxidants been shown to blunt adaptations to training? , there probably isn’t any need to worry. Most of the literature suggesting a negative effect of antioxidants on exercise adaptations used supraphysiologic doses of vitamin C, vitamin E, ALA, and/or NAC - all of which scavenge reactive oxygen species, which is the likely mechanism behind blunting exercise adaptations. Polyphenols on the other hand, act as intracellular stressors and upregulate endogenous production of antioxidants. For this reason, any negative interaction between training and the polyphenols in Hormetea is very unlikely.
Adding a bit of fat will maximize the absorption of the polyphenols in Hormetea. We recommend 1-3 teaspoons of coconut milk,coconut oil, PHAT FIBRE, MCT oil, heavy cream, etc.
To maximize sulforaphane, make Hormetea hot, using the method described above. Then chill to make your cold beverage. Here is a recipe created by Toréa Rodriguez for a Hormetea frappuccino that trumps anything you could buy at Starbucks:
1.5 c ice, cubed or crushed
0.5 c nut or coconut milk
0.5 c water
1.5 t NBT Hormetea
1 t vanilla
1 or 2 dates, or 1" of frozen banana for desired sweetness level.
Dust the top with freshly grated nutmeg
Place all ingredients into a high-powered blender. Blend on high for a few minutes to desired consistency.
We encourage people to expose themselves to a variety of hormetic stressors and recognize that capturing all the benefits of exercise in a pill (or tea) is impossible. So keep taking those cold showers, using the sauna, challenging yourself with metabolically-demanding exercise, and getting a bit of color in the summer months. Additionally, you can now drink Hormetea to reap the benefits of not too few, not too many, but a healthy amount of those reactive oxygen species that help create a more resilient human.
You can buy Hormetea here. We’d love to hear what you think of it, so please leave your thoughts in the comments section below!
1. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11: 298–300. Available: https://www.ncbi.nlm.nih.gov/pubmed/13332224
2. Senger DR, Li D, Jaminet S-C, Cao S. Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet. PLoS One. 2016;11: e0148042. doi:10.1371/journal.pone.0148042
3. Murugaiyah V, Mattson MP. Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective. Neurochem Int. 2015;89: 271–280. doi:10.1016/j.neuint.2015.03.009
4. Coe S, Ryan L. Impact of polyphenol-rich sources on acute postprandial glycaemia: a systematic review. J Nutr Sci. 2016;5: e24. doi:10.1017/jns.2016.11
5. Rebello CJ, Burton J, Heiman M, Greenway FL. Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial. J Diabetes Complications. 2015;29: 1272–1276. doi:10.1016/j.jdiacomp.2015.08.023
6. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study. J Crohns Colitis. 2013;7: 271–279. doi:10.1016/j.crohns.2012.07.010
7. Riso P, Klimis-Zacas D, Del Bo’ C, Martini D, Campolo J, Vendrame S, et al. Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr. 2013;52: 949–961. doi:10.1007/s00394-012-0402-9
8. McAnulty LS, Collier SR, Landram MJ, Whittaker DS, Isaacs SE, Klemka JM, et al. Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res. 2014;34: 577–584. doi:10.1016/j.nutres.2014.07.002
9. Schrager MA, Hilton J, Gould R, Kelly VE. Effects of blueberry supplementation on measures of functional mobility in older adults. Appl Physiol Nutr Metab. 2015;40: 543–549. doi:10.1139/apnm-2014-0247
10. Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr. 2008;87: 778–784. Available: https://www.ncbi.nlm.nih.gov/pubmed/18326618
11. Park S-K, Jung I-C, Lee WK, Lee YS, Park HK, Go HJ, et al. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food. 2011;14: 334–343. doi:10.1089/jmf.2009.1374
12. Lochocka K, Bajerska J, Glapa A, Fidler-Witon E, Nowak JK, Szczapa T, et al. Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study. Sci Rep. 2015;5: 12015. doi:10.1038/srep12015
13. Wang P, Heber D, Henning SM. Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo. Food Funct. 2012;3: 635–642. doi:10.1039/c2fo10254d
14. Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 2016;115: 226–238. doi:10.1017/S0007114515004328
15. Kar P, Laight D, Rooprai HK, Shaw KM, Cummings M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med. 2009;26: 526–531. doi:10.1111/j.1464-5491.2009.02727.x
16. Razavi S-M, Gholamin S, Eskandari A, Mohsenian N, Ghorbanihaghjo A, Delazar A, et al. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia. J Med Food. 2013;16: 255–258. doi:10.1089/jmf.2012.2408
17. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15: 195–218. doi:10.1208/s12248-012-9432-8
18. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64: 353–356. doi:10.1055/s-2006-957450
19. Amin F, Islam N, Anila N, Gilani AH. Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial. Complement Ther Med. 2015;23: 165–174. doi:10.1016/j.ctim.2015.01.008
20. Lee M-S, Wahlqvist ML, Chou Y-C, Fang W-H, Lee J-T, Kuan J-C, et al. Turmeric improves post-prandial working memory in pre-diabetes independent of insulin. Asia Pac J Clin Nutr. 2014;23: 581–591. doi:10.6133/apjcn.2014.23.4.24
21. Thamlikitkul V, Bunyapraphatsara N, Dechatiwongse T, Theerapong S, Chantrakul C, Thanaveerasuwan T, et al. Randomized double blind study of Curcuma domestica Val. for dyspepsia. J Med Assoc Thai. 1989;72: 613–620. Available: https://www.ncbi.nlm.nih.gov/pubmed/2699615
22. Ghosh SS, Bie J, Wang J, Ghosh S. Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice--role of intestinal permeability and macrophage activation. PLoS One. 2014;9: e108577. doi:10.1371/journal.pone.0108577
23. Wu QJ, Yang Y, Vogtmann E, Wang J, Han LH, Li HL, et al. Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies. Ann Oncol. 2013;24: 1079–1087. doi:10.1093/annonc/mds601
24. Zhang X, Shu X-O, Xiang Y-B, Yang G, Li H, Gao J, et al. Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality. Am J Clin Nutr. 2011;94: 240–246. doi:10.3945/ajcn.110.009340
25. Cho YA, Kim J. Dietary Factors Affecting Thyroid Cancer Risk: A Meta-Analysis. Nutr Cancer. 2015;67: 811–817. doi:10.1080/01635581.2015.1040517
26. Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P. Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. Int J Food Sci Nutr. 2012;63: 767–771. doi:10.3109/09637486.2012.665043
27. Black AM, Armstrong EA, Scott O, Juurlink BJH, Yager JY. Broccoli sprout supplementation during pregnancy prevents brain injury in the newborn rat following placental insufficiency. Behav Brain Res. 2015;291: 289–298. doi:10.1016/j.bbr.2015.05.033
28. Singh K, Connors SL, Macklin EA, Smith KD, Fahey JW, Talalay P, et al. Sulforaphane treatment of autism spectrum disorder (ASD). Proc Natl Acad Sci U S A. 2014;111: 15550–15555. doi:10.1073/pnas.1416940111
29. Kikuchi M, Ushida Y, Shiozawa H, Umeda R, Tsuruya K, Aoki Y, et al. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol. 2015;21: 12457–12467. doi:10.3748/wjg.v21.i43.12457
30. Egner PA, Chen J-G, Zarth AT, Ng DK, Wang J-B, Kensler KH, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res . 2014;7: 813–823. doi:10.1158/1940-6207.CAPR-14-0103
31. Matusheski NV, Juvik JA, Jeffery EH. Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli. Phytochemistry. 2004;65: 1273–1281. doi:10.1016/j.phytochem.2004.04.013
32. Craig DM, Ashcroft SP, Belew MY, Stocks B, Currell K, Baar K, et al. Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis. Front Physiol. 2015;6: 296. doi:10.3389/fphys.2015.00296
33. Merry TL, Ristow M. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol. 2016;594: 5135–5147. doi:10.1113/JP270654